This gives us the confidence to state that we have developed a fully functional model of the human blood-brain barrier,” said VIIBRE staff scientist Jacquelyn Brown, who is first author of the paper “Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor” that described this achievement in the journal Biomicrofluidics. “The NVU has reached the point where we can begin using it to test different drugs and compounds,” observed team member Donna Webb, associate professor of biological sciences who is interested in studying how different substances affect synapses — the junctions between neurons. “There is an urgent need for us to understand how various substances affect cognitive processes. When we do, we will be in for a number of surprises! Providing the first continuous picture of inflammation response Already, the VIBRE team has used the NVU to overcome a basic limitation of existing studies of brain inflammation, which have only produced snapshots of the process at various stages. http://harperfostercode.denaliinstitute.org/2016/07/29/as-an-incoming-college-student-it-could-be-helpful-to-know-how-your-parents-can-help-you-achieve-your-dream-of-pursuing-collegeBecause the NVU can be continuously monitored, it has provided the first dynamic view of how the brain and blood-brain barrier respond to systemic inflammation. http://go.xperian.ir/consultantinterviewcourse10048These results are summarized in a paper titled “Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit” accepted for publication in the Journal of Neuroinflammation. The scientists exposed the NVU to two different compounds known to induce brain inflammation: a large molecule found on the surface of certain bacteria called lipopolysaccharide and a “cocktail” of small proteins called cytokines that play an important role in immune response to inflammation. “One of our biggest surprises was the discovery that a critical component in the blood-brain barrier’s response to these compounds was to begin increasing protein synthesis,” said Brown. “Next will be to find out which proteins it is making and what they do.” The researchers also found that the blood vessels in the barrier respond to inflammation by pumping up their metabolic rate while the metabolism of the brain cells slows down.
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He also becomes the first player to score 60 points since Lakers guard Kobe Bryant hit the mark exactly against the Jazz on the final night of the 2015-16 season. I felt great, obviously, Thompson told NBA TV during a post-game interview. It was fun. I was in a great rhythm. I took all good shots, for the most part. Still missed a few wide open threes I wish I could get back. It was a fun night, to say the least. Your browser does not support iframes. Thompson shot 21-33 from the field, 8-14 on three-pointers and 10-11 from the free-throw line. His outburst included 40 points in the first half, with 23 coming in the second quarter.
For the original version including any supplementary images or video, visit http://www.si.com/nba/2016/12/06/golden-state-warriors-indiana-pacers-klay-thompson-60-points